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KMID : 0360319930250060928
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Journal of Korean Cancer Research Association
1993 Volume.25 No. 6 p.928 ~ p.934
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The Effect of Adjuvant CMF(Cyclophosphamide, Methotrexate, 5-FU) Chemotherapy of Breast Cancer
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Jegal Young-Jong
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Abstract
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The breast cancer is the most frequently detectable carcinoma at western women. It also has been increasing tendency in Korea.
The first therapeutic method is radical mastectomy but its usefulness is limited, so that adjuvant chemotherapy has been more advanced.
The authors analyzed the chemotherapeutic effects and toxicities of 42 patients with CMF chemotherapy following radical mastectomy of breast cancer, and compared with 50 patients without chemotherapy after radical mastectomy in Chonnam University
Hospital from 1985 to 1989, the following results were obtained.
1) The comparative relapse-free rate at three years was significantly higher in chemotherapy group(chemotherapy group 76.2%, control group 48%). After three years, 92.8% of patients given chemotherapy and 76.2% of control group remained alive.
The
difference between chemotherapeutic group and control group was statistically significant(p<0.05).
And that was no statistically significant result in breast cancer stage I and II, but in the stage III, the three year relapse free rate of chemotherapeutic group was 54.6%, it was higher than that of control group(15.8%).
2) The three year relapse free rates were markedly increased in the patients with chemotherapy compared with control group, regardless of number of axillary lymph node metastasis.
3) The most common relapse site was reginal-local lymph nodes(4 cases) in the chemotherapeutic group, and the lung metastasis(9 cases) in the control group.
4) Mest common complication of the chemotherapy was Leukopenia(40.9%), but it was moderate & acceptable.
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